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Mitosis
This course provides a rigorous, lab-informed exploration of mitosis from foundational concepts to modern experimental a...
1078
Views
Sections
1. Foundations of Cell Division and Mitosis10 views
Establishes core concepts, terminology, evolutionary context, and why mitosis matters for growth, maintenance, and development.
15 topics (15 versions)
1.1Roles of Mitosis in Multicellular Life
6
1.2Mitosis Versus Meiosis
4
1.3Chromosome Architecture Basics
1.4Chromatin States and Compaction
1.5Ploidy and Karyotypes
1.6Cell Types and Proliferative Capacity
1.7Tissue Growth and Homeostasis
1.8Developmental Contexts of Mitosis
1.9Regeneration and Wound Healing
1.10Cell Division Terminology
1.11Historical Milestones in Cytology
1.12Model Organisms for Mitosis
1.13Evolutionary Conservation of Machinery
1.14Overview of Mitotic Timeline
1.15Energetic and Metabolic Demands
2. Cell Cycle Architecture and Checkpoints2 views
Explains G1, S, G2, and M phases, their control logic, and how checkpoints coordinate accurate division.
15 topics (15 versions)
2.1G1 Phase Control
2
2.2S Phase DNA Replication
2.3G2 Phase Preparation
2.4M Phase Overview
2.5G1 S Checkpoint
2.6G2 M Checkpoint
2.7Cyclin Oscillation Dynamics
2.8Origin Licensing and Firing
2.9DNA Damage Response Pathways
2.10Cell Size and Growth Coordination
2.11Quiescence and G0
2.12Mitotic Entry Triggers
2.13Cell Cycle Feedback Loops
2.14Variability and Cell Cycle Noise
2.15Cell Cycle in Different Organisms
3. Prophase and Prometaphase Mechanics3 views
Covers chromosome condensation, nuclear envelope breakdown, spindle assembly, and initial kinetochore attachments.
15 topics (15 versions)
3.1Chromosome Condensation
3
3.2Condensin Complex Function
3.3Cohesin Establishment and Maintenance
3.4Centrosome Duplication
3.5Centrosome Separation
3.6Nuclear Envelope Breakdown
3.7Nuclear Lamina Disassembly
3.8Kinetochore Assembly
3.9Spindle Assembly Pathways
3.10Ran GTP Gradient
3.11Microtubule Nucleation Sites
3.12Motor Protein Roles
3.13Astral Microtubules
3.14Search and Capture Mechanism
3.15Early Error Correction
4. Metaphase Alignment and Spindle Dynamics3 views
Explores congression, bi-orientation, tension sensing, and stabilization of kinetochore-microtubule attachments.
15 topics (15 versions)
4.1Chromosome Congression
3
4.2Bi-orientation Establishment
4.3Tension Sensing at Kinetochores
4.4Aurora B Error Correction
4.5Stable End-On Attachments
4.6Kinetochore Microtubule Dynamics
4.7Microtubule Flux
4.8Chromosome Oscillations
4.9Metaphase Plate Geometry
4.10Spindle Length Regulation
4.11Merotelic Attachment Prevention
4.12Cohesin Protection at Centromeres
4.13SAC Satisfaction Requirements
4.14Spindle Orientation Cues
4.15Metaphase Duration Variability
5. Anaphase Segregation and Force Generation1 views
Details APC/C-driven transition, cohesin cleavage, and mechanics of chromosome movement and spindle elongation.
15 topics (15 versions)
5.1APC C Activation
1
5.2Securin Degradation
5.3Separase Activation
5.4Cohesin Cleavage
5.5Anaphase A Mechanics
5.6Anaphase B Mechanics
5.7Spindle Midzone Formation
5.8Motor Coordination and Sliding
5.9Poleward Flux Acceleration
5.10Laggard Chromosomes
5.11Anaphase Bridges
5.12Spatial Cdk1 Activity Gradients
5.13PP1 and PP2A Regulation
5.14Error Resolution in Anaphase
5.15Timing and Irreversibility
6. Telophase and Cytokinesis4 views
Covers nuclear reassembly, chromatin decondensation, contractile ring formation, and abscission mechanisms.
15 topics (15 versions)
6.1Nuclear Envelope Reassembly
4
6.2Nuclear Pore Complex Insertion
6.3Chromatin Decondensation
6.4Centralspindlin Function
6.5RhoA Activation at the Cortex
6.6Contractile Ring Assembly
6.7Actomyosin Ring Dynamics
6.8Cleavage Furrow Ingression
6.9Midbody Formation
6.10ESCRT III Mediated Abscission
6.11Abscission Timing Control
6.12Organelle Partitioning
6.13Cleavage Plane Positioning
6.14Cytokinesis Failure Outcomes
6.15Binucleation and Polyploidy
7. Molecular Control of Mitosis4 views
Integrates cyclin-CDK engines, APC/C regulation, checkpoints, kinases, and phosphatases into a systems view.
15 topics (15 versions)
7.1Cyclin CDK Core Engine
5
7.2Cdc25 and Wee1 Switches
7.3APC C Cofactors Cdc20 and Cdh1
7.4Ubiquitin Proteasome Regulation
7.5Spindle Assembly Checkpoint Core
7.6Mitotic Checkpoint Complex
7.7Aurora Kinase Family
7.8Polo Like Kinase 1
7.9Nek Kinases in Mitosis
7.10Greatwall PP2A B55 Pathway
7.11Phosphatase Targeting and Timing
7.12Substrate Degradation Motifs
7.13Spatial Gradients and Compartments
7.14Mitotic Exit Network Concepts
7.15Feedback and Bistability
8. Spindle, Kinetochores, and Microtubule Dynamics3 views
Dissects structural modules that capture, stabilize, and move chromosomes within the mitotic spindle.
15 topics (15 versions)
8.1Centrosome Structure and Function
3
8.2Acentrosomal Spindle Assembly
8.3Gamma TuRC Nucleation
8.4Augmin Dependent Amplification
8.5Kinetochore Architecture
8.6KMN Network Components
8.7Ndc80 Complex Mechanics
8.8Plus End Tracking Proteins
8.9CLASP and CLIP Roles
8.10Dynein at Kinetochores
8.11K Fiber Maturation
8.12Microtubule Dynamic Instability
8.13Catastrophe and Rescue Control
8.14Spindle Matrix Hypotheses
8.15Spindle Elasticity and Mechanics
9. Mitotic Errors, Aneuploidy, and Disease3 views
Connects missegregation mechanisms to chromosomal instability, developmental disorders, and cancer therapies.
15 topics (15 versions)
9.1Aneuploidy Mechanisms
3
9.2Chromosomal Instability CIN
9.3Whole Genome Doubling
9.4Micronuclei and DNA Damage
9.5Chromothripsis and Kataegis
9.6Cohesionopathies and Disease
9.7Centrosome Amplification
9.8Spindle Toxins in Therapy
9.9Taxanes and Vinca Alkaloids
9.10Kinesin 5 Inhibitors
9.11Resistance Mechanisms
9.12SAC Defects in Tumors
9.13Biomarkers of Mitotic Error
9.14Mitotic Catastrophe Pathways
9.15Clinical Mitotic Index
10. Methods and Quantitative Analysis in Mitosis4 views
Presents imaging, perturbation, and modeling approaches to measure and analyze mitotic processes.
15 topics (15 versions)
10.1Live Cell Imaging Strategies
3
10.2Fluorescent Protein Tagging
10.3Super Resolution Microscopy
10.4FRAP and Photoactivation
10.5FRET Reporters for CDK
10.6Laser Ablation Assays
10.7Optical Tweezers Measurements
10.8Computational Image Analysis
10.9Single Cell Lineage Tracking
10.10Force Inference from Motion
10.11Synchronization Techniques
10.12Flow Cytometry Cell Cycle
1
10.13RNAi and CRISPR Screens
10.14Organoid and In Vivo Models
10.15Stochastic Modeling of Mitosis