Chapters

1Foundations of Cell Division and Mitosis

2Cell Cycle Architecture and Checkpoints

3Prophase and Prometaphase Mechanics

4Metaphase Alignment and Spindle Dynamics

5Anaphase Segregation and Force Generation

6Telophase and Cytokinesis

7Molecular Control of Mitosis

Cyclin CDK Core Engine Cdc25 and Wee1 Switches APC C Cofactors Cdc20 and Cdh1 Ubiquitin Proteasome Regulation Spindle Assembly Checkpoint Core Mitotic Checkpoint Complex Aurora Kinase Family Polo Like Kinase 1 Nek Kinases in Mitosis Greatwall PP2A B55 Pathway Phosphatase Targeting and Timing Substrate Degradation Motifs Spatial Gradients and Compartments Mitotic Exit Network Concepts Feedback and Bistability

8Spindle, Kinetochores, and Microtubule Dynamics

9Mitotic Errors, Aneuploidy, and Disease

10Methods and Quantitative Analysis in Mitosis

Courses/Mitosis/Molecular Control of Mitosis

Molecular Control of Mitosis

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Integrates cyclin-CDK engines, APC/C regulation, checkpoints, kinases, and phosphatases into a systems view.

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Mitotic Exit Network Concepts

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